Pretreatment with Ajwa dates (Phoenix dactylifera Linn) prevents development of alloxan-induced diabetes in rats

<p><strong>ABSTRACT</strong></p>
 <p><strong>Background and Objective</strong>: A global increase in the prevalence of diabetes mellitus (DM) is associated with increased morbidity mortality. Oxidative stress a fundamental component pathogenesis DM Ajwa dates are known to have high antioxidant content, especially their seeds. Hence this study was designed determine preventive effects date fruit on alloxan-induced an experimental rat model.</p>
 <p><strong>Methods:</strong> This conducted at Post Graduate Medical Institute, Lahore, Pakistan. total forty Sprague-Dawley rats were divided into five groups eight animals each. Rats group normal control, whereas B induced intraperitoneal alloxan (160 mg/kg body weight) develop diabetes. Groups C, D, E fed diet supplemented flesh, seed, whole respectively for 1 week. Blood urine glucose levels measured days 0, 7 (pre-alloxan) 11, 14, 19 (post-alloxan). Serum insulin, homeostatic model assessment (HOMA) β-cell function (HOMA-β), insulin resistance (HOMA[1]IR) estimated terminally.</p>
 <p><strong>Results: </strong>Diabetes successfully all except control group. Ajwa-seed (D) showed relative induction three non-diabetic day 19. In E, had lower blood sugar than C (p = 0.010). HOMA-β HOMA-IR, revealed partial beta cells restoration D C. Insulin significantly higher, despite highest level (3.77 µIU/ml; p value <0.001) C.</p>
 <p><strong>Conclusion:</strong> seed powder appears provide protection against development by alloxan.</p>